Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages.
نویسندگان
چکیده
Rat surfactant protein D (SP-D) was shown to enhance the production of oxygen radicals by rat alveolar macrophages. This enhancement, which was determined by a lucigenin-dependent chemiluminescence assay, was maximal after 18 min at an SP-D concentration of 0.2 micrograms/ml. Surfactant lipids did not influence the stimulation of alveolar macrophages by SP-D, whereas the oxygen-radical production of these cells induced by surfactant protein A was inhibited by the lipids in a concentration-dependent manner.
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عنوان ژورنال:
- The Biochemical journal
دوره 286 ( Pt 1) شماره
صفحات -
تاریخ انتشار 1992